Synthesis of Tertiary Enamides by Ag2CO3-Promoted Pd-Catalyzed Alkenylation of Acyclic Secondary Amides

A. Delforge, I. Georgiou, A. Kremer, J. Wouters, D. Bonifazi,
Org. Lett.
, 2016, 18, 4844–4847.
DOI: 10.1021/acs.orglett.6b02305


A Pd-catalyzed methodology for the preparation of tertiary enamides from acyclic secondary amides and bromo acrylates under mild reaction conditions has been developed using [Pd2(dba)3], XantPhos, and Ag2CO3 as a base. The reaction occurs through a stereospecific metal-mediated oxidative-insertion mechanism.

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